WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist. WZ811 shows subnanomolar potency (EC50 = 0.3 nM) in an affinity binding assay. In addition, when subjected to in vitro functional evaluation, WZ811 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cyclic adenosine monophophate (cAMP) levels (EC50 = 1.2 nM) and SDF-1 induced Matrigel invasion (EC50 = 5.2 nM). The chemical structure of WZ811 is very similar to that of MSX-122.

MedKoo Cat#: 405250 Name: WZ811 CAS#: 55778-02-4 Chemical Formula: C18H18N4 Exact Mass: 290.15315 Molecular Weight: 290.36 Elemental Analysis: C, 74.46; H, 6.25; N, 19.30

Synonym: WZ811; WZ-811; WZ 811.

IUPAC/Chemical Name: N,N-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)

InChi Key: KBVFRXIGQQRMEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)

SMILES Code: C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1

Technical Data

Appearance: White solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

Additional Information

Related CAS# 55778-02-4 (WZ811 free base); 898190-81-3 (WZ811-2HCl salt); 897658-02-5(WZ811-4HCl salt)      

References

1: Kawatkar SP, Yan M, Gevariya H, Lim MY, Eisold S, Zhu X, Huang Z, An J. Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists. Exp Biol Med (Maywood). 2011 Jul 1;236(7):844-50. doi: 10.1258/ebm.2011.010345. Epub 2011 Jun 22. PubMed PMID: 21697335.

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