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Avexitide (Exendin (9-39)) 是特异竞争性的 glucagon-like peptide-1 (GLP-1) 受体拮抗剂。
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Avexitide Chemical Structure
CAS No. : 133514-43-9
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| Description |
Avexitide (Exendin (9-39)) is a specific and competitive GLP-1 receptor antagonist. |
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| In Vitro |
GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist[1]. |
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| In Vivo |
Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 -/- mice without affecting glucose tolerance[2]. |
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| Clinical Trial |
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| Molecular Weight |
3369.76 |
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| Formula |
C₁₄₉H₂₃₄N₄₀O₄₇S |
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| CAS No. |
133514-43-9 |
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| Sequence |
Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
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| Sequence Shortening |
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
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| SMILES |
[DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2] |
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| Shipping |
Room temperature in continental US; may vary elsewhere. |
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| Storage |
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| Solvent & Solubility |
In Vitro:
H2O : 50 mg/mL (14.84 mM; Need ultrasonic)
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| References |
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苏州蚂蚁淘生物科技有限公司专注于为科研工作者提供CST，Abcam，Sigma，biorbyt，Abclonal，AbD Serotec，GeneTex，ENZO，ScienCell，BI，Swant，emfret，Biovision，Roche，Millipore，BD，Life，eBioscience，Thermo，Qiagen，Santa，Peprotech，R&D，ImmunoStar，GenStar，GeneCopoeia，Cusabio，Bioss，NeoBioscience
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苏州蚂蚁淘生物科技有限公司专注于为科研工作者提供CST，Abcam，Sigma，biorbyt，Abclonal，AbD Serotec，GeneTex，ENZO，ScienCell，BI，Swant，emfret，Biovision，Roche，Millipore，BD，Life，eBioscience，Thermo，Qiagen，Santa，Peprotech，R&D，ImmunoStar，GenStar，GeneCopoeia，Cusabio，Bioss，NeoBioscience
全部回答 （共 2 条）
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