Section edited by David Stroncek
This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.
Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100days later, the W...Authors: Christopher J. Rogers, Robert J. Harman, Bruce A. Bunnell, Martin A. Schreiber, Charlie Xiang, Fu-Sheng Wang, Antonio F. Santidrian and Boris R. Minev
Glioblastoma stem-like cells (GSCs) are hypothesized to contribute to self-renewal and therapeutic resistance in glioblastoma multiforme (GBM) tumors. Constituting only a small percentage of cancer cells, GSCs...Authors: Xu Wang, Wenjuan Zhou, Xian Li, Jun Ren, Guangyu Ji, Jingyi Du, Wenyu Tian, Qian Liu and Aijun Hao
We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and in... Genetically engineered T cells have become an important therapy for B-cell malignancies. Measuring the efficiency of vector integration into the T cell genome is important for assessing the potency and safety ...Authors: Alex Lu, Hui Liu, Rongye Shi, Yihua Cai, Jinxia Ma, Lipei Shao, Victor Rong, Nikolaos Gkitsas, Hong Lei, Steven L. Highfill, Sandhya Panch, David F. Stroncek and Ping Jin
Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder. Reactivation of John Cunningham virus leads to oligodendrocyte infection with lysis and consequent axonal loss due to demyelination. ...Authors: M. J. Steinhardt, E. Wiercinska, M. Pham, G. U. Grigoleit, A. Mazzoni, M. Da-Via, X. Zhou, K. Meckel, K. Nickel, J. Duell, F. C. Krummenast, S. Kraus, C. Hopkinson, B. Weissbrich, W. M眉llges, G. Stoll
Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific therapeutics. Recently, mesenchymal stem cell...Authors: Shuo Wang, Songjie Cai, Weitao Zhang, Xigao Liu, Yan Li, Chao Zhang, Yigang Zeng, Ming Xu, Ruiming Rong, Tianshu Yang, Benkang Shi, Anil Chandraker, Cheng Yang and Tongyu Zhu
Adoptive transfer of virus-specific T cells (VSTs) represents a prophylactic and curative approach for opportunistic viral infections and reactivations after transplantation. However, inadequate frequencies of...Authors: Nele Carolin Heinemann, Sabine Tischer-Zimmermann, Torge Christian Wittke, Julian Eigendorf, Arno Kerling, Theodor Framke, Anette Melk, Hans-Gert Heuft, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper
The skin is the largest organ of the human body. Upon injury, the skin triggers a sequence of signaling pathways that induce epithelial proliferation, migration, and ultimately, the re-establishment of the epi...Authors: Carlos H. V. Nascimento-Filho, Ericka J. D. Silveira, Eny M. Goloni-Bertollo, Lelia Batista de Souza, Cristiane H. Squarize and Rogerio M. Castilho
Cell proliferation and death are key components of wound healing and tissue repair. Telocytes (TCs) represent a newly discovered cell type that can protect tissue from acute injury via cell鈥揷ell communication ...Authors: Lu Wang, Dongli Song, Chuanyuan Wei, Cheng Chen, Yanwen Yang, Xinyi Deng and Jianying Gu
Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin he...Authors: Tingting Weng, Pan Wu, Wei Zhang, Yurong Zheng, Qiong Li, Ronghua Jin, Haojiao Chen, Chuangang You, Songxue Guo, Chunmao Han and Xingang Wang
Mesenchymal stromal cells (MSCs) have attracted intense interest due to their powerful intrinsic properties of self-regeneration, immunomodulation and multi-potency, as well as being readily available and easy...Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu and Fei Mao
Bone marrow mononuclear cells have been successfully utilized for numerous regenerative purposes. In the current study, patients suffering from erectile dysfunction (ED) unresponsive to phosphodiesterase 5 inh...Authors: Mark Bieri, Elias Said, Gabrielle Antonini, Donald Dickerson, Jorge Tuma, Courtney E. Bartlett, Amit N. Patel and Alexander Gershman
Prostate cancer is one of the most common adult malignancies in men, and nearly all patients with metastatic prostate cancer can develop and receive resistance to primary androgen deprivation therapy (ADT), a ... Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal ste...Authors: Fang-Zhu Wan, Kai-Hua Chen, Yong-Chu Sun, Xi-Chan Chen, Ren-Ba Liang, Li Chen and Xiao-Dong Zhu
A worldwide lack of donor corneas demands the bioengineered corneas be developed as an alternative. The primary objective of the current study was to evaluate the efficacy of acellular porcine corneal stroma (...Authors: Saiqun Li, Meng Li, Li Gu, Lulu Peng, Yuqing Deng, Jing Zhong, Bowen Wang, Qian Wang, Yichen Xiao and Jin Yuan
Innovative human stromal cell therapeutics require xeno-free culture conditions. Various formulations of human platelet lysate (HPL) are efficient alternatives for fetal bovine serum (FBS). However, a consiste...Authors: Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk and Katharina Schallmoser
Telocytes (TCs) have the capacity of cell鈥揷ell communication with adjacent cells within the tissue, contributing to tissue repair and recovery from injury. The present study aims at investigating the molecular...Authors: Dongli Song, Li Tang, Jianan Huang, Lu Wang, Tao Zeng and Xiangdong Wang
Delayed bone healing, especially in long bones poses one of the biggest problems in orthopeadic and reconstructive surgery and causes tremendous costs every year. There is a need for exploring the causes in or...Authors: Johannes M. Wagner, Sonja V. Schmidt, Mehran Dadras, Julika Huber, Christoph Wallner, Stephanie Dittfeld, Mustafa Becerikli, Henriette Jaurich, Felix Reinkemeier, Marius Drysch, Marcus Lehnhardt and Bj枚rn Behr
The liver is supplied by a dual blood supply, including the portal venous system and the hepatic arterial system; thus, the liver organ is exposed to multiple gut microbial products, metabolic products, and to... Mesenchymal stem cells (MSCs) represent an invaluable asset for the field of cell therapy. Human Bone marrow-derived MSCs (hBM-MSCs) are one of the most commonly used cell types in clinical trials. They are cu... The aim of this systematic review study is to summarize the current knowledge of ovarian tissue transplantation and provide insight on ovarian function, fertility and reproductive outcome following ovarian tis...Authors: Sepideh Sheshpari, Mahnaz Shahnazi, Halimeh Mobarak, Shahin Ahmadian, Alberto Miranda Bedate, Ziba Nariman-Saleh-Fam, Mohammad Nouri, Reza Rahbarghazi and Mahdi Mahdipour
Although translational research for drug development can provide patients with valuable therapeutic resources it is not without risk, especially in the early-phase trials that present the highest degree of unc... Liver, as a vital organ, is responsible for a wide range of biological functions to maintain homeostasis and any type of damages to hepatic tissue contributes to disease progression and death. Viral infection,...Authors: Vahid Hosseini, Nazila Fathi Maroufi, Sepideh Saghati, Nahideh Asadi, Masoud Darabi, Saeed Nazari Soltan Ahmad, Hosseini Hosseinkhani and Reza Rahbarghazi
When bone marrow is repeatedly filtered through porous material, the mesenchymal stem cells (MSCs) in the bone marrow can adhere to the outer and inner walls of the carrier material to become enriched locally,...Authors: Wenxiang Chu, Yifu Zhuang, Yaokai Gan, Xin Wang, Tingting Tang and Kerong Dai
We have entered the post-antibiotic era. Phage therapy has recently been given renewed attention because bacteriophages are easily available and can kill bacteria. Many reports have demonstrated successful pha... The colorectum includes ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. Different sites of colorectal cancer (CRC) are different in many aspects, including clinical symptoms, bi...Authors: Yang Xi, Pan Yuefen, Wu Wei, Qi Quan, Zhuang Jing, Xu Jiamin and Han Shuwen
Liver cancer is the second leading causes of cancer-related death globally. Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of tumors. Therefore, it is necessary to expl...Authors: Juhua Zhuang, Yanan Song, Ying Ye, Saifei He, Xing Ma, Miao Zhang, Jing Ni, Jiening Wang and Wei Xia
The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upst...Authors: Feng He, Zonghui Xiao, Hailan Yao, Sen Li, Miao Feng, Wei Wang, Zhewei Liu, Zhuo Liu and Jianxin Wu
Mesenchymal stem cells (MSCs) are attractive cell-therapy candidates. Despite their popularity and promise, there is no uniform method of preparation of MSCs. Typically, cells are cryopreserved in liquid nitro...Authors: Ben Antebi, Amber M. Asher, Luis A. Rodriguez II, Robbie K. Moore, Arezoo Mohammadipoor and Leopoldo C. Cancio
Glutathione S-transferase A3 (GSTA3) is known as an antioxidative protease, however, the crucial role of GSTA3 in liver fibrosis remains unclear. As a recently we developed water-soluble pyridone agent with antif...Authors: Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao and Yu Peng
Correction to this article has been published inJournal of Translational Medicine 2020 18:182 Deep venous thrombosis (DVT) of lower extremities is a common thrombotic disease, occurring either in isolation or as a complication of other diseases or procedures. MiR-21 is one of important microRNAs which ...Authors: Xiaolong Du, Lei Hong, Lili Sun, Hongfei Sang, Aiming Qian, Wendong Li, Hao Zhuang, Huoqi Liang, Dandan Song, Chenglong Li, Wenbin Wang and Xiaoqiang Li
Mesenchymal stromal cells (MSC) demonstrate innate and regulatory immunologic functions and have been widely explored for cell therapy applications. Mechanisms by which MSCs achieve therapeutic effects are the... Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of ...Authors: Rida Al-Rifai, Philippe Nguyen, Nicole Bouland, Christine Terryn, Lukshe Kanagaratnam, Ga毛l Poitevin, Caroline Fran莽ois, Catherine Boisson-Vidal, Marie-Antoinette Sevestre and Claire Tournois
The rapid evolution of cell-based immunotherapies such as chimeric antigen receptor T-cells for treatment of hematological cancers has precipitated the need for a platform to expand these cells ex vivo in a sa... Diabetic cardiomyopathy (DCM) is a common complication of diabetes and is characterized by chronic myocardial inflammation. Mesenchymal stem cell (MSC) infusions have recently been suggested to alleviate myoca...Authors: Liyuan Jin, Zihui Deng, Jinying Zhang, Chen Yang, Jiejie Liu, Weidong Han, Ping Ye, Yiling Si and Guanghui Chen
Here, we isolated, expanded and functionally characterized regulatory T cells (Tregs) from patients with end stage kidney and liver disease, waiting for kidney/liver transplantation (KT/LT), with the aim to es...Authors: Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Vigan貌, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Sollazzo, Antonio Curti
The relationship between the tissue injury healing response and development of heterotopic ossification (HO) is poorly understood. Here we compare a rat blast model and human traumatized muscle from a blast in...Authors: Jaira F. de Vasconcellos, Sonia Zicari, Stephen D. Fernicola, Daniel W. Griffin, Youngmi Ji, Emily H. Shin, Patrick Jones, Gregory T. Christopherson, Husain Bharmal, Carl Cirino, Thao Nguyen, Astor Robertson, Vincent D. Pellegrini Jr. and Leon J. Nesti
The molecular pathways that drive bone marrow myeloid progenitors (BMMP) development are very well understood and include a tight controlled multi-stage gene hierarch. Monocytes are versatile cells that displa...Authors: Mariana Cabanel, Thayse Pinheiro da Costa, Marcia Cury EL-Cheikh and Katia Carneiro
Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used to overcome this hurdl...Authors: Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn and Helene Roelofs
The use of 鈥渙ff-the-shelf鈥?cellular therapy products derived from healthy donors addresses many of the challenges associated with customized cell products. However, the potential of allogeneic cell products to...Authors: David H. Quach, Luis Becerra-Dominguez, Rayne H. Rouce and Cliona M. Rooney
The clinical significance of stem cell therapy in the treatment of dilated cardiomyopathy remains unclear. This systemic appraisal and meta-analysis aimed to assess the efficacy and safety of stem cell therapy...Authors: Shu-Ling Rong, Ze-Kun Wang, Xue-Dong Zhou, Xiao-Lin Wang, Zhi-Ming Yang and Bao Li
Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells (BMSC-EVs) can play important roles in the repair of injured tissues. However, no reports have investigated the role and un... 鈥淣anomedicine鈥?is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While 鈥?..Authors: Jie Feng, Chester E. Markwalter, Chang Tian, Madeleine Armstrong and Robert K. Prud鈥檋omme
Telocytes play key roles in maintenance of organ/tissue function and prevention of organ injury. However, there are great challenges to investigate telocytes functions using primary telocytes, due to the diffi...Authors: Dongli Song, Menglin Xu, Ruixue Qi, Ruihua Ma, Yile Zhou, Duojiao Wu, Hao Fang and Xiangdong Wang
Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein ...Authors: Ya-Chao Tao, Meng-Lan Wang, Dong-Bo Wu, Chen Luo, Hong Tang and En-Qiang Chen
Interferon gamma (IFN纬) plays an important role in the development of chronic lung diseases via the production of inflammatory mediators, although the exact mechanism remains unclear. The present study aimed a... The role of 纬未 T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding 纬未 T cells in ovarian cancer (...Authors: Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang and Shiyang Pan
Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem... Cancer stem cells (CSC) may respond to chemotherapy differently from other tumor cells.Authors: Keith M. Skubitz, Jon D. Wilson, Edward Y. Cheng, Bruce R. Lindgren, Kristin L. M. Boylan and Amy P. N. Skubitz
Cell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current ...Authors: Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber and Shibani Pati
Speed64 days to first decision for reviewed manuscripts only32 days to first decision for all manuscripts122days from submission to acceptance10 days from acceptance to publication
Citation Impact4.098-2-year Impact Factor4.301-5-year Impact Factor1.133 -Source Normalized Impactper Paper (SNIP)1.591 - SCImago Journal Rank (SJR)
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