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4-(4-(Dimethylamino)benzyl)-N-hydroxybenzamide

Chemical

C16H18N2O2

270.3

1392835-67-4

≥98% (HPLC)

Light blue solid.

Soluble in DMSO, methanol or ethanol.

Determined by 1H-NMR.

MNOOUMMGNAQTKF-UHFFFAOYSA-N

AMBIENT

+4°C

-20°C

Keep cool and dry.Protect from light.

Stable for at least 2 years after receipt when stored at -20°C.

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• Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC₅₀ =12nM). Displays high selectivity over HDAC1 (IC₅₀=6.8µM).
• Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular α-tubulin hyperacetylation.
• HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

Product References

Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)

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