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蚂蚁淘在线 / 品牌中心 / Xona品牌新闻

Adipogen/Thiocolchicine/AG-CN2-0074-M005/5 mg

作者： 时间：2024-11-14 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW CAS RTECS Source/Host Chemicals Purity Chemicals Appearance Solubility Identity InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
10-Demethoxy-10-methylthiocolchicine; NSC 186301
Chemical
C22H25NO5S
415.5
2730-71-4
GH0878800
Semisynthetic.
≥95% (NMR)
Yellow solid.
Soluble in ethanol or acetone. Almost insoluble in water or ether.
Determined by 1H-NMR.
CMEGANPVAXDBPL-UHFFFAOYSA-N
AMBIENT
+4°C
-20°C
Protect from light and moisture.
Stable for at least 2 years after receipt when stored at -20°C.
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  • Antimitotic alkaloid.
  • Tubulin polymerization and microtubule assembly inhibitor.
  • Axonal cytoskeleton modulator.
  • Inhibitor of autophagosome-lysosome fusion.
  • Apoptosis inducer.
  • Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
Product References
  • Association of thiocolchicine with tubulin: R.M. Chabin & S.B. Hastie; BBRC 161, 544 (1989)
  • Effect of tubulin binding and self-association on the near-ultraviolet circular dichroic spectra of colchicine and analogues; R.M. Chabin, et al.; Biochemistry 29, 1869 (1990)
  • N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties: G.J. Kang, et al.; J. Biol. Chem. 265, 10255 (1990)
  • Antitumor agents-CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis: Q. Shi, et al.; Bioorg. Med. Chem. 5, 2277 (1997)
  • Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines: R. De Vincenzo, et al.; Anticancer Drug Des. 13, 19 (1998)
  • Biological evaluation on different human cancer cell lines of novel colchicine analogs: R. De Vincenzo, et al.; Oncol. Res. 11, 145 (1999)
  • Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve: P. Ferri, et al.; Exp. Toxicol. Pathol. 54, 211 (2002)
  • Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors: G. Raspaglio, et al.; Biochem. Pharmacol. 69, 113 (2005)
  • Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III: D. Passarella, et al.; Bioorg. Med. Chem. 16, 6269 (2008)
  • Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates: D. Passarella, et al.; Eur. J. Med. Chem. 45, 219 (2010)

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