Background
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
Specifications
Additional Names
Osteogenin, BMP-3ATested Application
n/aDisclaimer
This product is for research use only.Purity
Greater than 95% by SDS-PAGE gel and HPLC analyses.Storage
The lyophilized BMP-3 recombinant protein is stable for at least 2 years from date of receipt at -20ËšC. Reconstituted BMP-3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20ËšC. As with any protein, exposing BMP-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.Preparation
Biological activity was determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells. Endotoxin level is less than 0.1 ng per μg (1EU/μg).Reactivity
n/aSource
E.coliLocation
MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC RSpecies Reactivity
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