CL-03-PDE4

Name

Phosphodiesterase 4 (PDE4) ACTOne^TM Stable Cell Line

Description

This cell line is a HEK293-CNG cell line that expresses a recombinant human PDE4. HEK293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization.

Application

cAMP dependent human PDE4 cell-based assay;

cell-based high-throughput screening of human PDE4 inhibitors

Size

1x 10⁶ cells

Detection

FlexStation or Microplate reader