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商品描述
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- Product NameNFκB-p105 Antibody
- Descriptionnuclear factor kappa B subunit 1(NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) Protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof
- Catalog NoB0021
- ReactivityHuman, Mouse
- ApplicationsWB, IHC-p, IF/ICC, ELISA
- ModificationUnmodified/Total
- SourcePolyclonal Rabbit
- DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
- PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration1 mg/ml
- Storage and Stability-20°C/1 year
- Other NameNFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- Molecular Weight (Da)105356
- Gene NameNFKB1
- Protein NameNuclear factor NF-kappa-B p105 subunit
- Human Gene ID4790
- Human Swiss Prot No.P19838
- ImmunogenThe antiserum was produced against synthesized peptide derived from human NF-kappaB p105/p50. AA range:896-945
- SpecificityNFκB-p105 Polyclonal Antibody detects endogenous levels of NFκB-p105 protein.
- FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
