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Toll-like Receptor 9; CD289

Monoclonal Antibody

ABM1C51

Mouse IgG1κ

Recombinant human TLR9 protein (aa 100-290).

FITC

Flow Cytometry: (0.5μg/106 cells)Optimal conditions must be determined individually for each application.

HumanMouse

Recognizes human and mouse TLR9.

Protein G purified.

0.2mg/ml

Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.

Q9NR96

BLUE ICE

+4°C

+4°C

Do not freeze.Protect from light.

Stable for at least 6 months after receipt when stored at +4°C.

No

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TLR9 (Toll-like Receptor 9) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 is expressed by numerous cells of the immune system such as B lymphocytes, monocytes, natural killer (NK) cells and plasmacytoid dendritic cells. It is expressed intracellularly, within the endosomal compartments and functions to alert the immune system of viral and bacterial infections by binding to DNA rich in CpG motifs. This nucleotide-sensing TLR is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (also called oligodinucleotides, ODNs), and consequently signals via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response and eventually activation of a Th1-biased adaptive immune attack. Specific TLR9 agonists have been shown to have substantial antitumor activity, making the TLR9 signaling pathway an interesting target for therapeutic research.

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