other brands: NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscienceproduct type: antibodyproduct name: CD171 Monoclonal Antibody (UJ127)catalog: MA5-14140quantity: 500µLprice: US 390clonality: monoclonalhost: mouseconjugate: nonconjugatedclone name: UJ127reactivity: hamsters, human, mouse, pigapplication: western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen sectionmore info or order: Invitrogen product webpagePublished Application/Species/Sample/DilutionReferenceimmunohistochemistry; human; 1:100Geels Y, van der Putten L, van Tilborg A, Lurkin I, Zwarthoff E, Pijnenborg J, et al. Immunohistochemical and genetic profiles of endometrioid endometrial carcinoma arising from atrophic endometrium. Gynecol Oncol. 2015;137:245-51 pubmedpublisher immunohistochemistry; mouse; 1:40; fig8immunohistochemistry; human; 1:40; fig1ELISA; human; 1 ug/mlSung S, Wu I, Chuang P, Petros J, Wu H, Zeng H, et al. Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth. Oncotarget. 2014;5:9911-29 pubmed immunohistochemistry; pig; 1:1000Choi H, Lee Y, Lee Y, Park J, Min K, Park H. Inflammatory responses in the muscle coat of stomach and small bowel in the postoperative ileus model of guinea pig. Yonsei Med J. 2013;54:1336-41 pubmedpublisher immunohistochemistry; human; 1:50Blessmann M, Gröbe A, Quaas A, Kaifi J, Mistakidis G, Bernreuther C, et al. Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:239-44 pubmedpublisher immunocytochemistry; humanimmunohistochemistry; humanReinisch C, Tschachler E. The dimensions and characteristics of the subepidermal nerve plexus in human skin--terminal Schwann cells constitute a substantial cell population within the superficial dermis. J Dermatol Sci. 2012;65:162-9 pubmedpublisher flow cytometry; humanDou X, Menkari C, Shanmugasundararaj S, Miller K, Charness M. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011;286:16131-9 pubmedpublisher immunohistochemistry; human; 1:150Rawnaq T, Quaas A, Zander H, Gros S, Reichelt U, Blessmann M, et al. L1 is highly expressed in tumors of the nervous system: a study of over 8000 human tissues. J Surg Res. 2012;173:314-9 pubmedpublisher flow cytometry; humanimmunoprecipitation; humanimmunohistochemistry; humanChen M, Lee C, Leland H, Silletti S. Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells. Tumour Biol. 2011;32:347-57 pubmedpublisher immunohistochemistry; humanNovelli M, Rossi S, Rodriguez Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57:259-70 pubmedpublisher immunohistochemistry; humanimmunoprecipitation; hamstersChen M, Lee C, Leland H, Lin G, Montgomery A, Silletti S. Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration. Mol Biol Cell. 2010;21:1671-85 pubmedpublisher western blot; humanSon M, Woolard K, Nam D, Lee J, Fine H. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4:440-52 pubmedpublisher immunohistochemistry; human; 1:50Rawnaq T, Kleinhans H, Uto M, Schurr P, Reichelt U, Cataldegirmen G, et al. Subset of esophageal adenocarcinoma expresses adhesion molecule l1 in contrast to squamous cell carcinoma. Anticancer Res. 2009;29:1195-9 pubmed immunohistochemistry; human; 1:50Wachowiak R, Fiegel H, Kaifi J, Quaas A, Krickhahn A, Schurr P, et al. L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors. Ann Surg Oncol. 2007;14:3575-80 pubmed immunohistochemistry; human; 1:150Kaifi J, Reichelt U, Quaas A, Schurr P, Wachowiak R, Yekebas E, et al. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Mod Pathol. 2007;20:1183-90 pubmed immunohistochemistry; human; 1:50Kaifi J, Strelow A, Schurr P, Reichelt U, Yekebas E, Wachowiak R, et al. L1 (CD171) is highly expressed in gastrointestinal stromal tumors. Mod Pathol. 2006;19:399-406 pubmed western blot; mouse; fig1Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery A. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004;279:28880-8 pubmed Ivanova I, Arulanantham S, Barr K, Cepeda M, Parkins K, Hamilton A, et al. Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. Cancers (Basel). 2019;11: pubmedpublisher Fukushima N, Sato N, Prasad N, Leach S, Hruban R, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004;23:9042-51 pubmed Gelman M, Ye X, Stull R, Suhy D, Jin L, Ng D, et al. Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen. Oncogene. 2004;23:8158-70 pubmed Oliva A, James C, Kingman C, Craighead H, Banker G. Patterning axonal guidance molecules using a novel strategy for microcontact printing. Neurochem Res. 2003;28:1639-48 pubmed Applications: Immunohistochemistry (Frozen): 1:1000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mLSpecies: Human, MouseClone: UJ127Isotype: IgG1, kappaStorage: Description: The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.Immunogen: Homogenous suspension of 16 week human fetal brainFormat: LiquidApplications w/Dilutions: Immunohistochemistry (Frozen): 1:1000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mLAliases: CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1more info or order: Invitrogen product webpageThermo Fisher Scientific81 Wyman StreetWaltham, MA USA 02451https://www.thermofisher.com800-678-5599headquarters: USA

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