Description:
The peroxisome-proliferator activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily of transcription factors. PPARgamma is important to a variety of biological processes, such as adipocyte differentiation, glucose homeostasis, lipid trafficking as well as vascular function and hypertension. PPARgamma exerts its effects by regulating target gene transcription in a ligand-dependent manner. Upon activation, the PPARgamma-RXR heterodimer binds to specific DNA sequences on the target gene promoter and leads to transcriptional regulation.Applicable Grid:
List of Applicable Genes
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