Bone Marrow Mononuclear Cells (BMMC) are located in the bone marrow and have regenerative capabilities. Primary BMMC are a heterogeneous population of single nucleus cells which include hematopoietic stem cells, hematopoietic progenitor cells, immature monocytes, and immature lymphocytes [1]. Recent studies suggest that BMMC are suitable as a cell therapy to treat a variety of diseases such as cardiovascular disease, type 1 diabetes, and ischemic stroke [2, 3, 4]. BMMC may also be used for bone tissue engineering [1]. Primary mouse BMMC (MBMMC) can be utilized to further study BMMC as a potential cell therapy.
MBMMC from ScienCell Research Laboratories are isolated from healthy adult C57BL/6 mouse bone marrow. MBMMC are depleted of erythrocytes and bone marrow macrophages, cryopreserved immediately after isolation, and delivered frozen. MBMMC are a mixed population of cells that include hematopoietic stem cells and progenitor cells, monocytes, and lymphocytes. Each vial contains at least 10 million cells in 1 ml volume. MBMMC are quality control tested for viability. MBMMC are negative for mycoplasma, bacteria, yeast, and fungi. MBMMC can be maintained for a short period of time in culture using the conditions provided by ScienCell Research Laboratories and are not intended for long-term culture.
Specifications:
| Catalog No. | M1930-57 |
| Country of Manufacture | United States |
| Product Code | MBMMC |
| Size/Quantity | 10 million cells in 1 ml volume |
| Product Use | MBMMC are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Henrich D, Verboket R, Schaible A, Kontradowitz K, Oppermann E, Brune J, Nau C, Meier S, Bonig H, Marzi I, Seebach C. (2015) \"Characterization of bone marrow mononuclear cells on biomaterials for bone tissue engineering in vitro.\" Biomed Res Int. 10: 1-12. [2] Savitz S, Misra V, Kasam M, Juneja H., Cox C, Alderman S, et al. (2011). \"Intravenous autologous bone marrow mononuclear cells for ischemic stroke.\" Ann Neurol. 70:59-69. [3]Fotino C, Ricordi C, Lauriola V, Alejandro R, Pileggi A. (2010) \"Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes.\" Rev Diabet Stud. 7(2): 144-157. [4] Arnous S, Mozid A, Martin J, Mathur A. (2012) \"Bone marrow mononuclear cells and acute myocardial infarction.\" Stem Cell Res. 3(1): 2-10. |
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