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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
ACE2AntibodyProperties Description Anti-ACE2(RABBIT)Antibody-600-401-X58 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName ACE2 RelevantLinks UniProtKB-Q9BYF1 GeneID-59272 NCBI-NP_068576 |
ACE2AntibodyDescription
Background
Angiotensin-convertingenzyme2(ACE2)playsacentralroleinvascular,renal,andmyocardialphysiology.IncontrasttoitshomologACE,ACE2expressionisrestrictedtoheart,kidney,andtestis.Recently.ACE2hasalsobeenshowntobeafunctionalreceptoroftheSARScoronavirus.ThenormalfunctionofACE2istoconverttheinactivevasoconstrictorangiotensinI(AngI)toAng1-9andtheactiveformAngIItoAng1-7,unlikeACE,whichconvertsAngItoAngII.Whiletheroleofthesevasoactivepeptidesisnotwellunderstood,lackofACE2expressioninace2-/ace2-miceleadstoseverelyreducedcardiaccontractility,indicatingitsimportanceinregulatingheartfunction.
Synonyms
ACE2Antibody,ACEH,Angiotensin-convertingenzyme2,ACE-relatedcarboxypeptidase,ACEH
Immunogen
Anti-ACE2antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidsneartheinternalregionofhumanACE2.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-ACE2AntibodyhasbeentestedforuseinELISA,Immunofluorescence,ImmunohistochemistryandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandat~90kDainsizecorrespondingtoACE2proteinbyWesternBlottingintheappropriatecelllysateorextract.
Purity/Specifity
Anti-ACE2Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.Anti-ACE2hasnocrossresponsetoACE1.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
