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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
APOBEC3GAntibodyProperties Description Anti-APOBEC3G(RABBIT)Antibody-600-401-Y47 Host Rabbit TargetSpecies Human KnownCrossReactivity Human Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName APOBEC3G RelevantLinks UniProtKB-Q9HC16 GeneID-60489 NCBI-NP_068594 |
APOBEC3GAntibodyDescription
Background
TheApoliproteinBmRNA-editing,enzyme-catalytic,polypeptide-like(APOBEC)3isamulti-isoformmemberofthecytidinedeaminasefamilyofenzymesthatactonmonomericnucleosideandnucleotidesubstrates.SimilartoTRIM5awhichtargetsincomingretroviralcapsids,APOBEC3playsamajorroleincellulardefenseagainstretroviralinfectionasatleasttwoisoforms,APOBEC3GandtoalesserextentAPOBEC3F,canbeincorporatedHIV-1virionsandinducehypermutationinthenewlysynthesizedviralDNAandthusdestabilizetheviralgenome.ThisinnatemechanismofretroviralresistanceiscounteractedbytheHIV-1VifproteinbyinducingtheubiquitizationanddegradationofAPOBEC3G;asingleaminoacidsubstitution(D128K)blocksAPOBEC3Gdepletionwithoutaffectingitsinhibitoryactivity.
Synonyms
APOBEC3GAntibody,A3G,ARCD,ARP9,ARP-9,CEM15,CEM-15,MDS019,bK150C2.7,dJ494G10.1APOBEC-relatedcytidinedeaminase,APOBEC-relatedprotein
Immunogen
Anti-APOBEC3Gantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingto15aminoacidsneartheamino-terminusofhumanAPOBEC3G.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-APOBEC3GAntibodyhasbeentestedforuseinELISA,WesternBlotting,andImmunohistochemistry.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately46kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-APOBEC3GAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.APOBEC3GantibodywillalsodetecttheAPOBEC3Fisoform.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
