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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
AnthraxEdemaFactorAntibodyProperties Description Anti-AnthraxEdemaFactor(RABBIT)Antibody-600-401-Y19 Host Rabbit TargetSpecies Bacillus KnownCrossReactivity Bacillus Clonality Polyclonal Application ELISA:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName pxo1_122 RelevantLinks UniProtKB-P40136 GeneID-3361726 NCBI-P40136 |
AnthraxEdemaFactorAntibodyDescription
Background
Anthraxinfectionisinitiatedbytheinhalation,ingestion,orcutaneouscontactwithBacillusanthracisendospores.B.anthracisproducesthreepolypeptidesthatcomprisetheanthraxtoxin:protectiveantigen(PA),lethalfactor(LF),andedemafactor(EF).PAbindstotworelatedproteinsonthecellsurface;thesearetermedtumorepithelialMarker8(TEM8)/anthraxtoxinreceptor(ATR)andcapillarymorphogenesisprotein2(CMG2),althoughitisstillunclearwhichisphysiologicallyrelevant.FollowingPAbindingtoitsreceptor,PAiscleavedintotwofragmentsbyafurin-likeprotease.TheboundfragmentbindsbothLFandEF;theresultingcomplexisthenendocytosedwhichallowsthetranslocationofLFandEFintothecytoplasm.EFisacalmodulinandCa++-dependentadenylatecyclaseresponsIBLefortheedemaseeninthedisease.ItisthoughttobenefittheB.anthracisbacteriabyinhibitingcellsofthehostimmunesystem.
Synonyms
AnthraxEdemaFactorAntibody,Calmodulin-sensitiveadenylatecyclase,ATPpyrophosphate-lyase,EF
Immunogen
Anti-AnthraxEdemaFactorantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingto16aminoacidsneartheC-terminusoftheAnthraxedemafactorprotein.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AnthraxEdemaFactorAntibodyhasbeentestedforuseinELISA.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately92kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-AnthraxEdemaFactorAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAnthraxEdemaFactorfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
