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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
AKT1S1AntibodyProperties Description Anti-AKT1S1(RABBIT)Antibody-600-401-Y00 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application ELISA:1:10,000-1:20,000 IFMicroscopy:UserOptimized WesternBlot:1-2µg/mL Immunohistochemistry:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName AKT1S1 RelevantLinks UniProtKB-Q96B36 GeneID-84335 NCBI-NP_115751 |
AKT1S1AntibodyDescription
Background
TheAktsignalingpathwaycontributestotheregulationofapoptosisafteravarietyofcelldeathsignals.AKT1S1,alsoknownasPRAS40,isaproline-richsubstrateofthekinaseAKT1andisthoughttoplayaroleinneuroprotectionmediatedbynervegrowthfactor(NGF)aftertransientfocalcerebralischemia(1).AKT1S1isalsoasubstrateandpotentialregulatorofmammaliantargetofrapamycin(mTOR),aserine/threoninekinasethatregulatescellgrowthandcellcycle,andanegativeregulatorofautophagy(2).Treatmentwiththeinsulin-likegrowthfactor-1(IGF1)caninduscethephosphorylationofAKT1S1viathePI3K/AKTsignalingpathwayinPC12cells(3).
Synonyms
AKT1S1Antibody,Lobe,PRAS40,Proline-richAKT1substrate1,40kDaproline-richAKTsubstrate
Immunogen
Anti-AKT1S1antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha19aminoacidpeptideneartheC-terminusofhumanAKT1S1.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AKT1S1AntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunohistochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately28kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-AKT1S1Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.AKT1S1antibodyishuman,mouseandratreactive.AtleastthreeisoformsofAKT1S1areknowntoexist.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
