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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
Akirin2AntibodyProperties Description Anti-Akirin2(RABBIT)Antibody-600-401-X97 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1µg/mL PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName AKIRIN2 RelevantLinks UniProtKB-Q53H80 GeneID-55122 NCBI-EAW48578 |
Akirin2AntibodyDescription
Background
Thehighlyconserved,nuclear-localizedAkirin1andAkirin2proteinscriticallyregulatethetranscriptionofNF-kB-dependentgenesandarerequiredfordefenseagainstGram-negativebacteriaintheimmunedeficiencyandNF-kBpathways.Akirin1isdispensableinthemouse,andneitherknockoutmicenorcellsderivedfromthemhaveobviousdistinctivephenotypes.Incontrast,Akirin2isrequiredfordevelopmentinthemouseandknockoutofbothAkirinhomologsinmiceshowthatAkirin2isrequireddownstreamoftoll-likereceptor(TLR),TNF-aandIL-1bsignaling,andfortheproductionofIL-6.Akirin2isfunctionallyclosertothesinglegeneinDrosophila,asthehomozygousnullD.melanogasterAkirinmutantsshowasimilar,mid-to-earlyembryonicdeath.
Synonyms
Akirin2Antibody,FBI1,C6orf166,dJ486L4.2,Akirin-2
Immunogen
Anti-Akirin2antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha15aminoacidsyntheticpeptideneartheinternalregionofthehumanAkirin2.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-Akirin2AntibodyhasbeentestedforuseinELISAandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately37kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-Akirin2Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAkirin2fromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
