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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
AIFM3AntibodyProperties Description Anti-AIFM3(RABBIT)Antibody-600-401-X85 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName AIFM3 RelevantLinks UniProtKB-Q96NN9 GeneID-150209 NCBI-Q96NN9 |
AIFM3AntibodyDescription
Background
Apoptosis,alsoknownasprogrammedcelldeath,playsmajorrolesindevelopmentandnormaltissueturnoverinadditiontotumorformation.Recentlyaproteinsimilartotheapoptosis-inducingfactor(AIF)wasclonedanddesignatedAIFL(alsoknownasAIFM3).AIFM3isexpressedubiquitouslyandispredominantlylocalizedtotheinnermembranesofmitochondria.UnlikeAIF,AIFM3doesnottranslocatetothenucleusuponinductionofapoptosis.However,overexpressionofAIFM3,likeAIF,inducedcytochromecreleasefromthemitochondria,cleavageofcaspase3,andultimatelyapoptosis,indicatingAIFM3inducesapoptosisthroughcaspaseactivation.MultipleisoformsofAIFM3areknowntoexist.
Synonyms
AIFM3Antibody,AIFL,AIFL,Apoptosis-inducingfactor3,Apoptosis-inducingfactor-likeprotein
Immunogen
Anti-AIFM3antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha16aminoacidsyntheticpeptidefromneartheN-terminusofhumanAIFM3.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AIFM3AntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunohistochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately67kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-AIFM3Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAIFM3fromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
