- Description
- Product Info
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- Downloads
- References
Description
Pravastatin is an inhibitor of HMG-CoA reductase that exhibits anti-hyperlipidemic, anticancer, antithrombotic, antioxidative, immunosuppressive, anti-allergic, and anti-asthma activities. Clinically, pravastatin increases expression of LDL receptors, inducing cellular LDL uptake to decrease levels of LDL and triglycerides and increase levels of HDL. In animal models of cancer, pravastatin increases the efficacy of bevacizumab when given in combination, further decreasing tumor growth and inhibiting angiogenesis and metastasis. Pravastatin inhibits thrombosis in animal models of atherosclerotic plaque rupture and decreases lucigenin-induced O2 radical formation in other in vivo models. Additionally, pravastatin downregulates expression of IL-17 and decreases production of Th4 cytokines and IgE, preventing airway inflammation in animal models of OVA-induced allergies.
Product Info
85956-22-5 |
≥92% |
C23H34O6 |
406.51 |
(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid lactone |
[(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
138-142°C |
Soluble in water. |
Shipping and Storage
4°C |
Ambient |
Downloads
P6800 MSDS PDF |
P6800 Info Sheet PDF |
Statins Flyer |
References
Lee SJ, Lee I, Lee J, et al. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2, BiP, and Hsp90α in human colorectal cancer. Br J Cancer. 2014 Jun 19. [Epub ahead of print]. PMID: 24945998.
Wu G, Xie Q, Xu L, et al. Pravastatin inhibits plaque rupture and subsequent thrombus formation in atherosclerotic rabbits with hyperlipidemia. Chem Pharm Bull (Tokyo). 2013;61(2):121-4. PMID: 23207681.
Luzak B, Rywaniak J, Stanczyk L, et al. Pravastatin and simvastatin improves acetylsalicylic acid-mediated in vitro blood platelet inhibition. Eur J Clin Invest. 2012 Aug;42(8):864-72. PMID: 22409214.
Kassan M, Montero MJ, Sevilla MA. In vitro antioxidant activity of pravastatin provides vascular protection. Eur J Pharmacol. 2010 Mar 25;630(1-3):107-11. PMID: 20044990.
Imamura M, Okunishi K, Ohtsu H, et al. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax. 2009 Jan;64(1):44-9. PMID: 18835962.
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