Description:

Isotype: Rabbit IgG Positive Control: Placenta, or Breast carcinoma Staining Pattern: Cytoplasmic Immunogen: A synthetic peptide derived from aa 160-173 of human MMP-14 protein. MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Additional Information:

Name Related Product Names Source Applications Clonality Format Reactivity Storage

MMP-14/MT1-MMP, Antibody

MMP-14 / MT1-MMP EPITOPE SPECIFIC RABBIT ANTIBODY MMP-14/MT1-MMP

Rabbit

IHC-P, WB

Polyclonal

1.0 ml affinity purified rabbit polyclonal antibody at 0.2mg/ ml in 10mM PBS, pH 7.4 with BSA and Sodium Azide.

Human

Ab with sodium azide is stable for 24 months when stored at 2-8C.

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