Product | ARMET Antibody |
Description | Affinity Purified Mesencephalic astrocyte-derived neurotrophic factor Antibody |
Verified Applications | ELISA, IHC, IP, WB |
Host | Rabbit |
Species Cross Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide taken within amino acid region 80-120 on human Mesencephalic astrocyte-derived neurotrophic factor. |
Accession # | NCBI: NP_006001 |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin | IgG |
Form | Affinity Purified |
Purification Method | Immobilized antigen affinity chromatography |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
ELISA | 1:50,000 |
| Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation | 1:200 |
Western Blot | 1:500 |
Protein | |
Uniprot # | P55145 |
Overview | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. |
Molecular Function | Growth factor |
Subcellular Location | Secreted, Endoplasmic reticulum, Extracellular space, Nucleus |
Expression | By endoplasmic reticulum stress. |
Structure | The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. |
Alternative Nomenclature | Arginine rich mutated in early stage tumors antibodyArginine rich protein antibody ARMET antibody ARP antibodyManf antibody Mesencephalic astrocyte derived neurotrophic factor antibody |
Protein information supplied by UniProt
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