Product | PERK Antibody |
Description | Affinity Purified Eukaryotic translation initiation factor 2-alpha kinase 3 Antibody |
Verified Applications | DB, ELISA, IHC, IP,WB |
Host | Chicken |
Species Cross Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein. |
Accession # | NCBI: NP_004827 |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.68-0.70 µg/µl in antibody stabilization buffer |
| Immunoglobulin | IgY |
Form | Affinity Purified |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
DB | 1:4,000 |
ELISA | 1:4,000 |
| Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation | 1:150 |
Western Blot | 1:500 |
Protein | |
Uniprot # | Q9NZJ5 |
Overview | Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
Molecular Function | Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Expression | Ubiquitous. A high level expression is seen in secretory tissues. |
Structure | Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2. |
Alternative Nomenclature | DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody WRS antibody |
>>> 更多资讯详情请访问蚂蚁淘商城
