Product | AGE Antibody |
Description | Affinity Purified Advance Glycated Endproduct Antibody |
Verified Applications | ELISA, WB |
Host | Rabbit |
Species Cross Reactivity | Bovine, Human, Monkey, Panda |
Immunogen | Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months. |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.55 µg/µl in antibody stabilization buffer |
Form | Affinity Purified |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
DB | 1:10,000 |
ELISA | 1:10,000 |
Western Blot | 1:500 |
Protein | |
Overview | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. |
Molecular Function | Inflammatory Response |
Subcellular Location | Isoform 1 : Cell membrane; Single-pass type I membrane protein Isoform 2 : Secreted Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein |
Expression | Endothelial cells. |
Structure | Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked. |
Alternative Nomenclature | Advanced glycation end products antibody AGEs antibody |
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