General Information

Product

TDRD1 Antibody

Description

Affinity Purified Tudor domain-containing protein 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 570-605 on TDRD1 protein.

Accession #

Gen Bank: BAG65177.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9BXT4

Overview

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage.

Molecular Function

metal ion binding

Subcellular Location

cytoplasm (Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body)

Expression

Testis and ovary specific. Also expressed in several cancers.

Alternative Nomenclature

Cancer/testis antigen 41.1 antibody

CT41.1 antibody

FLJ21082 antibody

MTR 1 antibody

Tudor domain containing protein 1 antibody