General Information

Product

Stra6 Antibody

Description

Affinity Purified Retinoic acid-responsive protein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 450-500 on human Stra6 protein.

Accession #

GenBank: BAB14122.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.69 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O70491

Overview

May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity.

Molecular Function

Receptor, Receptor activity

Subcellular Location

Cell membarane; Multi-pass membrane protein

Expression

Widely expressed in the embryo. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in the eye (retinal pigment epithelium), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (at protein level). Also detected in kidney, spleen, and female genital tract; and at lower levels in heart and lung.

Alternative Nomenclature

MCOPCB8 antibody

MCOPS9 antibody

PP14296 antibody

Stimulated by retinoic acid 6 homolog antibody

Stimulated by retinoic acid gene 6 protein homolog antibody

STRA6 antibody