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货号-规格 货期 价格 数量 abs132001-50ug 现货 ￥1500.00 - +abs132001-100ug 现货 ￥2300.00 - + 大包装询价 立即购买加入购物车 产品介绍 商品评论 FAQ 引用文献(20) 相关视频 商品相册 相关文档 概述 描述Actin, a ubiquitous eukaryotic protein, is the major component of the Cytoskeleton. At least six isoforms are known in mammals. Nonmuscle - and -actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility.
宿主 Rabbit 特异性 Beta actin antibody detects endogenous levels of total Beta actin. 反应种属 Human;Mouse;Rat;Pig;Zebrafish;Dog;Monkey;Fish 预测反应种属 Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse; 应用 WB 1:3000-1:20000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 免疫原 A synthesized peptide derived from human Beta actin. 性能 浓度 1mg/ml 纯化方法 The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . 类型 Polyclonal Antibody 储存/保存方法 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 存储溶液 Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. 靶标 背景说明 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 翻译后修饰 ISGylated.Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148). 细胞定位 Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane; UniPort P60709 Western blot analysis of Beta actin expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. 温馨提示：本产品仅作科研实验使用，不支持临床等研究 跳转 提示： 尊敬的客户您好，如果您对我们的产品有什么疑问或想要了解的，可以点击\"我要提问”按钮填写您的疑问。提交不成功？请联系info@absin.cn。 我要提问 A novel pathogenic splice site variation in STK11 gene results in Peutz–Jeghers syndrome
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Resveratrol Suppresses the Growth and Metastatic Potential of Cervical Cancer through Inhibiting STAT3Tyr705 PhosphorylationXiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang
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4,4′- 二异硫氰基芪 -2,2′- 二磺酸对脓毒症小鼠心肌炎性反应的作用及机制王 艳, 夏 琳, 蔡华忠, 熊御云
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Western blot analysis of Beta actin expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.Certificate of Analysis(COA)
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