- SAHA (Vorinostat)
- 探测系统
- 雌酮ELISA试剂盒
- 成分辅助试剂
- PGFM ELISA试剂盒
- Triiodothyronine (T3) ELISA Kit
- Pregnanediol-3-Glucuronide (PDG) ELISA Kit
- 别孕孕酮ELISA试剂盒
- 左炔诺孕酮（LNG）ELISA试剂盒
- Corticosterone Chemiluminescent ELISA Kit
- BRL-50481
- DHEA-S ELISA Kit
- 甲状腺素（T4）ELISA试剂盒
- BML-278
- IBMX
- Testosterone ELISA Kit
- IOX1型
- 谷胱甘肽比色反应杯检测试剂盒
- 心钠素ELISA试剂盒
- Sirtinol
- Retinol Binding Protein (RBP) Multi-Format ELISA Kit
- MultiSpecies
- USES-WesternblottingandChIP
- APPLICATIONS-ReactswithmammalianLysineSpecificDemethylase1
AbX™LSDRabbitPolyclonalAntibodyforWesternblottingandChIP.
Therearetwoknownclassesofhistonedemethylases(HDM),differingintheirreactionchemistry,coenzymeuseandreactionproducts.Flavin-dependentHDMsactonlyonmono-anddimethylatedlysinesandproducehydrogenperoxide,whereastheJumonji-containingHDMsareiron-dependentenzymesthatcanactonmono-,di-andtrimethylatedlysinesidechains,andalsoonmethylatedArginineresidues.Bothclassesalsoproduceformaldehydeasaproductofthedemethylationreaction.LSD1(Lysine-specificdemethylase1)isaflavindependentamineoxidaseandwasidentifiedasasubunitofdifferentcomplexesandhasbeenshowntobeinvolvedintranscriptionalrepressionofgenesthroughthedemethylationofmonomethylLys4anddimethylLys4HistoneH3.LSD1isalsoinvolvedintranscriptionalactivationthroughthedemethylationofmonomethylLys9anddimethylLys9HistoneH3.Itisalsoabletodemethylatebothmono-anddimethylLys370intheregulatorydomainofthetumorsuppressorp53.
