AbX^™HistoneH3RabbitPolyclonalAntibodyforWesternblottingandChIP.

Chromosomalsurfacesareornamentedwithavarietyofposttranslationalmodificationsofhistones,whicharerequiredfortheregulationofmanyoftheDNA-templatedprocesses.HistoneH3isoneofthefivemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongN-terminustail,H3isinvolvedwiththe‘beadsonastring’structureofthenucleosome.HistoneH3isthemostextensivelypost-translationallymodifiedofthefivehistones.Theterm“HistoneH3”aloneispurposelyambiguousinthatitdoesnotdistinguishbetweensequencevariantsormodificationstate.HistoneH3isanimportantproteinintheemergingfieldofepigenetics,whereitssequencevariantsandvariablemodificationstatesarethoughttoplayaroleintheregulationofgenes.Forexample,histonemethylationeitherontheirarginineand/orlysineresidues,yieldsamorediversearrayofcellularfunctions.

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