Product ID A9612Cas No. 1174043-16-3Purity ≥98%

• Description
• Product Info
• Shipping and Storage
• Downloads
• References

Description

AZD-2461 is a novel anticancer chemotherapeutic currently in clinical trials. This compound acts as a poly(ADP)-ribose polymerase-1 (PARP1) inhibitor, potentially beneficial in homologous recombination-deficient tumors such as BRCA1-associated cancers. Unlike most PARP inhibitors, AZD-2461 is not a substrate for P-glycoprotein and is thus unlikely to incur related resistance mechanisms.

Product Info

Cas No.PurityFormulaFormula Wt.IUPAC NameAppearance

1174043-16-3

≥98%

C22H22FN3O3

395.43

4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one

White to off white powder

Shipping and Storage

Store TempShip Temp

-20°C

Ambient

Downloads

Info SheetBrochures

A9612 Info Sheet PDF

PARP Inhibitors Flyer

References

Jaspers JE, Kersbergen A, Boon U, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81. PMID: 23103855.

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