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Adipogen/3-Deoxyaphidicolin/BVT-0451-M001/1 mg

作者： 时间：2024-09-20 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW CAS Source/Host Chemicals Purity Chemicals Appearance Solubility Identity Declaration InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
(+)-3-Deoxyaphidicolin
Chemical
C20H34O3
322.5
85483-00-7
Isolated from Phoma sp. BS 7210.
≥98% (HPLC)
White to off-white solid.
Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water.
Determined by 1H-NMR and MS.
Manufactured by BioViotica.
VHWTVINEPPOCLA-DTMQFJJTSA-N
AMBIENT
+4°C
+4°C
Protect from light when in solution.
Stable for at least 1 year after receipt when stored at +4°C.
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  • Inhibitor of eukaryotic DNA synthesis.
  • Mycotoxin.
  • Phytotoxic and cytotoxic agent.
  • Specific inhibitor of DNA polymerase α.
Product References
  • Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase α, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
  • 3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984)
  • Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985)
  • An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985)
  • Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase α in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987)
  • Structure-activity relationships for the inhibition of DNA polymerase α by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989)
  • Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)

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