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Pigment Epithelium-derived Factor; Stromal Cell-derived Factor 3; Serpin F1; Caspin

Protein

CHO cells

Mouse PEDF (aa 20-417) is fused at the C-terminus to a FLAG®-tag.

Mouse

~47kDa (SDS-PAGE)

≥95% (SDS-PAGE)

0.1mg/ml after reconstitution.

Reconstitute with 100μl sterile distilled water.

Lyophilized. Contains PBS.

UniProt link P97298: PEDF (mouse)

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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Pigment epithelium-derived factor (PEDF) is a 47kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and fetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.

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