More Information Product Details Synonyms Product Type Properties Source/Host Sequence Crossreactivity Specificity Biological Activity MW Purity Endotoxin Content Concentration Reconstitution Formulation Other Product Data Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet

Tumor Necrosis Factor Receptor Superfamily Member EDAR; Anhidrotic Ectodysplasin Receptor 1; Downless Homolog; EDA-A1 Receptor; Ectodermal Dysplasia Receptor; Ectodysplasin-A Receptor

Protein

CHO cells

The extracellular domain of human EDAR (aa 27-183) is fused at the C-terminus to the Fc portion of human IgG1.

HumanMouse

Binds to human and mouse EDA-A1.

Inhibits EDA-A1 activity.

~50kDa (SDS-PAGE)

≥95% (SDS-PAGE)

1mg/ml after reconstitution.

Reconstitute with 50μl sterile water.

Lyophilized. Contains PBS.

UniProt link Q9UNE0: EDAR (human)

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.

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