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Blastostimulina; Centelase; Emdecassol; Madecassol; Marticassol; FK1080; BRN 0078195; NSC 166062

Chemical

C48H78O19

959.1

16830-15-2

YU9625000

Isolated from Centella asiatica.

≥95% (NMR)

White solid.

Soluble in ethanol, methanol or pyridine. Insoluble in water.

Determined by 1H-NMR and 13C-NMR.

WYQVAPGDARQUBT-NXDSUYQXBS

AMBIENT

+4°C

+4°C

Keep cool and dry.

Stable for at least 2 years after receipt when stored at +4°C.

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• Antibacterial.
• Human collagen I synthesis inducer. Anti-wrinkle activity.
• Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth.
• Suppresses collagen expression and TGF-β/Smad signaling by inducing Smad7 and inhibiting TGF-βRI and TGF-βRII.
• Anti-inflammatory. Anti-gastric ulcer.
• Mitogen-activated protein kinases (MAPKs), nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) inhibitor.
• Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy.
• Anxiolytic.
• Antidepressant-like activity.
• Hepatoprotective effects.
• CYP2C19 and CYP3A4 inhibitor.
• Neuroprotective.
• Antileishmanial activity.
• cPLA2 and sPLA2 inhibitor.

Product References

In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica: A. Shukla, et al.; J. Ethnopharmacol. 65, 1 (1999)

In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins: J.H. Sampson, et al.; Phytomedicine 8, 230 (2001)

The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats: C.L. Cheng, et al.; Life Sci. 74, 2237 (2004)

Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats: J.S. Guo, et al.; Planta Med. 70, 1150 (2004)

Improving lip wrinkles: lipstick-related image analysis: J.S. Ryu, et al.; Skin Res. Technol. 11, 157 (2005)

Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling: J. Lee, et al.; Planta Med. 72, 324 (2006)

Anxiolytic-like effect of asiaticoside in mice: S.W. Chen, et al.; Pharmacol. Biochem. Behav. 85, 339 (2006)

Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts: S.H. Qi, et al.; Clin. Exp. Dermatol. 33, 171 (2008)

Antidepressant-like effect of asiaticoside in mice: X. Liang, et al.; Pharmacol. Biochem. Behav. 89, 444 (2008)

Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice: L. Zhang, et al.; Phytomedicine 17, 811 (2010)

Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts: B. Tang, et al.; Arch. Dermatol. Res. 303, 563 (2011)

In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450: T. Winitthana, et al.; Toxicol. In Vitro 25, 890 (2011)

Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax: C.L. Xu, et al.; Pharmacol. Biochem. Behav. 100, 413 (2012)

Asiaticoside induces tumour-necrosis-factor-α-mediated nitric oxide production to cure experimental visceral leishmaniasis caused by antimony-susceptible and -resistant Leishmania donovani strains: S.K. Bhaumik, et al.; J. Antimicrob. Chemother. 67, 910 (2012)

Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract: P.P. Defillipo, et al.; Nat. Prod. Commun. 7, 841 (2012)

Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model: J.H. Lee, et al.; Phytomedicine 19, 1223 (2012)

Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1: J. Wan, et al.; Phytother. Res. 27, 1136 (2013)

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