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NVP-BEZ235; BEZ-235

Chemical

C30H23N5O

469.6

915019-65-7

≥95%

Solid.

Soluble in DMSO or ethanol.

Manufactured by SynKinase.

Target: mTOR - PI3K | Kinase Group: Atypical (PIKK) | Substrate: Serine-ThreonineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

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AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.Product References

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. S.M. Maira, et al.; Mol. Cancer Ther. 7, 1851 (2008)

Recent results in protein kinase inhibition for tropical diseases. D.P. Rotella, et al.; Bioorg. Med. Chem. Lett. 22, 6788 (2012)

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