Product Specification:
| Alternative Name: | SerpinH1, Colligin, Gp46, Heat shock protein 47, Collagen-binding protein |
| Clone: | M16.10A1 |
| Host: | Mouse |
| Isotype: | IgG2bλ |
| Immunogen: | Native rat HSP47. |
| UniProt ID: | P50454 |
| GenBank ID: | X61598 |
| Species reactivity: | Human, Mouse, RatBovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:50)Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~47kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Hsp47, also known as colligin and gp46, is an ER-resident collagen-specific stress glycoprotein involved in the synthesis and assembly of varoius collagens as a molecular chaperone. Hsp47 is a member of the serpin superfamily, but localizes to the ER via binding of its C-terminal RDEL sequence to KDEL receptors in the ER. Hsp47 binds procollagen co-translationally as it enters the ER, and dissociates prior to its secretion. |
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