| Isotype | IgG |
| Product Type | Antigen Immunoaffinity Purified Polyclonal |
| Units | 100 µg |
| Host | Rabbit |
| Species reactivity | HumanMouseRat |
| Application | ImmunohistochemistryWestern Blotting |
BackgroundThe product of the DEGS1 gene is a member of the membrane fatty acid (sphingolipid delta 4) desaturase family. Reported to function byinserting double bonds at delta 4 position in fatty acids.DEGS1 is an intracellular enzyme. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. Two splice variants have been identified.
Synonyms: Migration-inducing gene 15 protein, MLD,dihydroceramide desaturase, sphingolipid delta 4 desaturase, DES1, MGC5079, DEGS
Source
Immunogen: Synthetic peptide derived from the human DEGS1 protein
Product
Product Form: Affinity Purified
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
ApplicationsAntibody can be used for Western blotting (1:400 starting dilution) and immunohistochemistry (10-15 µg/ml).Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: ELISA
Positive Control: Placenta, normal human brain
StorageProduct should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship on gel ice, store at -20ºC immediately upon arrival
CautionThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
References1. Cadena, D.L., et al. 'The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis.; Biochemistry 36:6960-6967(1997).2. Ternes, P., et al. 'Identification and characterization of a sphingolipid delta 4-desaturase family.; J. Biol. Chem. 277:25512-25518(2002).
Protein Reference(s)
Database Name: UniProt
Accession number: O15121 (Human) Q5XIF5 (Rat) O09005 (Mouse)
Species Accession: Human, Rat, Mouse
Safety Datasheet(s) for this product:NM_Sodium Azide/wp-content/uploads/SDS/Antibody SDS with Sodium Azide Noridic-MUbio.pdf
