OVERVIEW:

Synonyms	Monoclonal p53 antibody, Anti-p53 antibody, p 53 antibody, p53, p 53, p-53 antibody, p-53, p53 Oncoprotein antibody
Specificity	Human
Cross Reactivity	To be determined by end-user
Applications	IHC, WB
Immunogen	p53 antibody was raised in mouse using recombinant human p53 as the immunogen

SPECIFICATIONS:

Host	Mouse
Clone	Bp5312
Isotype	IgG2a
Source	Ascites
Method of Purification	p53 antibody was affinity purified with protein A
Form & Buffer	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3, reconstitute with 1 ml of distileld water

STORAGE & SAFETY:

Storage	Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage

Usage Assay Information:

Usage Recommendations	IHC: 25 ug/ml, WB: 25 ug/ml

GENERAL INFORMATION:

Biological Significance

p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome", the "guardian angel gene", and the "master watchman", referring to its role in conserving stability by preventing genome mutation.

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