OVERVIEW:

Synonyms	Monoclonal MDB3 antibody, Anti-MDB3 antibody, MBD-3, MBD 3 antibody, MBD 3, MBD-3 antibody, methyl-CpG binding Domain Protein 3 antibody, MBD3
Specificity	Human
Applications	WB
Immunogen	MBD3 antibody was raised in rabit using a synthetic peptide corresponding to part of the C terminal of human MBD3 (EELARDGEAPLDKAC) as the immunogen

SPECIFICATIONS:

Host	Mouse
Clone	3A3
Isotype	IgG1
Source	Supernatant
Method of Purification	MBD3 antibody was affinity purified with antigen peptides
Form & Buffer	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3, reconstitute with 1 ml of deionised water

STORAGE & SAFETY:

Storage	Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage

Usage Assay Information:

Usage Recommendations	WB: 0.1 ug/ml

GENERAL INFORMATION:

Biological Significance	Methylation at CpG dinucleotides in genomic DNA is a fundamental epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl-CpG binding domain (MBD) can bind to single methylated CpGs and most of them are involved in transcription control. So far, five vertebrate MBD proteins have been described as MBD family members: BD1, MBD2, MBD3, MBD4 and MECP2.

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