OVERVIEW:
| Monoclonal TP53 antibody, Anti-TP53 antibody, Cellular tumor antigen p53 antibody, TP53, Tumor protein p53 antibody, TP-53 antibody, Phosphoprotein p53 antibody, TP 53 antibody, TP 53, p53 antibody, TP-53 |
| Human |
| WB |
SPECIFICATIONS:
| Mouse |
| 4 B1 |
| IgG |
| Supplied in lyophilized form with PBS buffer. Reconstitute in 100 ul of distilled water. |
| 1 mg/ml |
STORAGE & SAFETY:
| Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze-thaw cycles. |
Usage Assay Information:
| WB: 0.2 ug/ml |
GENERAL INFORMATION:
| Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where its believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. |
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