OVERVIEW:
| Monoclonal APP antibody, Anti-APP antibody, Amyloid Precursor Protein antibody, APP C-terminus antibody |
| Human |
| IHC, WB |
| APP antibody was raised in mouse using a full length recombinant protein of human APP (NP_000475) produced in HEK293T cells, as the immunogen. |
SPECIFICATIONS:
| Mouse |
| 5C5 |
| IgG1 |
| APP antibody was purified by affinity chromatography. |
| Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 500 ug-1 mg/ml |
STORAGE & SAFETY:
| Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Usage Assay Information:
| IHC: 1:50, WB: 1:2000 |
GENERAL INFORMATION:
| Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (ABeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimers disease patients. |
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