OVERVIEW:
| Monoclonal BTRC antibody, Anti-BTRC antibody, Beta-transducin repeat containing antibody, FBXW1A antibody, bTrCP antibody, bTrCP1 antibody, E3RSIkappaB antibody, pIkappaBalpha-E3 receptor subunit antibody, Fwd1 antibody, FBW1A antibody |
| Human |
| WB |
| BTRC antibody was raised in mouse using a human fragment corresponding to amino acids 52-354 of human BTRC (NP_378663) produced in E. coli as the immunogen. |
SPECIFICATIONS:
| Mouse |
| 1D4 |
| IgG1 |
| BTRC antibody was purified by affinity chromatography. |
| Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 500 ug-1 mg/ml |
STORAGE & SAFETY:
| Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Usage Assay Information:
| WB: 1:500 |
GENERAL INFORMATION:
| BTRC is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitin ation. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbwsclass; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to XenopusbTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 tothe proteolytic machinery. |
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