品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
| ProductDetails | |
|---|---|
| Synonyms | ADP-ribosylCyclase1;CyclicADP-riboseHydrolase1;ADPRC1;T10 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofhumanCD38(aa43-300)isfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| MW | ~70kDa(SDS-PAGE) |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <5eu g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitutewith100µlsterilewater.Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceP28907:CD38(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD38,alsoknownascyclicADPribosehydrolaseisaglycoproteinfoundonthesurfaceofmanyimmunecells(whitebloodcells),includingCD4+,CD8+,Blymphocytesandnaturalkillercells.CD38alsofunctionsincelladhesion,signaltransductionandcalciumsignaling.CD38isamultifunctionalectoenzymethatcatalyzesthesynthesisandhydrolysisofcyclicADP-ribose(cADPR)fromNAD+toADP-ribose.ThesereactionproductsareessentialfortheregulationofintracellularCa2+.ThelossofCD38functionisassociatedwithimpairedimmuneresponses,metabolicdisturbances,andbehavioralmodificationsincludingsocialamnesiapossIBLyrelatedtoautism.TheCD38proteinisaMarkerofcellactivation.IthasbeenconnectedtoHIVinfection,leukemias,myelomas,solidtumors,typeIIdiabetesmellitusandbonemetabolism,aswellassomegeneticallydeterminedconditions.
