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蚂蚁淘在线 / 品牌中心 / Adipogen品牌新闻

Adipogen/MS-275/AG-CR1-0032-M001/1 mg

作者： 时间：2025-01-15 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW CAS Purity Chemicals Appearance Solubility InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
N-(2-Aminophenyl)-4-[N-(pyridine-3-ylmethoxy-carbonyl)aminomethyl]benzamide; MS-27-275
Chemical
C21H20N4O3
376.4
209783-80-2
≥98% (NMR)
Off-white to tan solid.
Soluble in DMSO or methanol.
LTWMTJUZATWRDH-UHFFFAOYSA-N
AMBIENT
+4°C
-20°C
Protect from light.
Stable for at least 2 years after receipt when stored at -20°C.
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  • HDAC 1 inhibitor [1, 2].
  • Antitumor compound [1-3].
  • Antiproliferative [2].
  • TGF-β type II receptor inducer [2].
  • Apoptosis inducer [4].
  • Anti-inflammatory [5].
  • Angiogenesis inhibitor [6].
  • Review [7].
  • Promotes either self-renewal or differentiation of embryonic stem cells [8].
Product References
  • A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors: A. Saito, et al.; PNAS 96, 4592 (1999)
  • MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells: B.I. Lee, et al.; Cancer Res. 61, 931 (2001)
  • MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors: J. Jaboin, et al.; Cancer Res. 62, 6108 (2002)
  • The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1: R.R. Rosato, et al.; Cancer Res. 63, 3637 (2003)
  • MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis: Z.Y. Zhang, et al.; Neuroscience 169, 370 (2010)
  • S-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo: R.K. Srivastava, et al.; Mol. Cancer Ther. 9, 3254 (2010)
  • MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent: H. Hess-Stumpp, et al.; Int. J. Biochem. Cell Biol. 39, 1388 (2007)
  • Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming: A. Kretsovali, et al.; Stem Cells Int. 2012, 1 (2012)

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