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蚂蚁淘在线 / 品牌中心 / Adipogen品牌新闻

Adipogen/Glyburide (USP)/AG-CR1-3613-G001/1 g

作者： 时间：2024-09-20 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW Merck Index CAS Purity Chemicals Appearance Solubility InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
Diabeta; Glibenclamide
Chemical
C23H28ClN3O5S
494.0
14: 4478
10238-21-8
≥98%
White to off-white solid.
Soluble in DMSO. Slightly soluble (
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
AMBIENT
+4°C
-20°C
Keep cool and dry.
Stable for at least 2 years after receipt when stored at -20°C.
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  • Antidiabetic compound.
  • Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1).
  • Causes cell membrane depolarization and opening of voltage-dependent calcium channel.
  • Increases intracellular calcium and stimulates insulin secretion in β cells
  • NLRP3 inflammasome inhibitor.
  • Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor.
  • Shown to have anti-leishmanial activity.
  • Potential inhibitor of collagenases.
Product References
  • Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects: J.M. Feldman; Pharmacotherapy 5, 43 (1985)
  • The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells: H. Schmid-Antomarchi, et al.; J. Biol. Chem. 262, 15840 (1987)
  • Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels: M. Fosset, et al.; J. Biol. Chem. 263, 7933 (1988)
  • Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator: C.M. McNicholas, et al.; PNAS 93, 8083 (1996)
  • The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells: L. Payen, et al.; Br. J. Pharmacol. 132, 778 (2001)
  • Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis: X. Serrano-Martin, et al.; Antimicrob. Agents Chemother. 50, 4214 (2006)
  • CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three: P. Melin, et al.; Biochim. Biophys. Acta 1768, 2438 (2007)
  • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome: M. Lamkanfi, et al.; J. Cell. Biol. 187, 61 (2009)
  • Glyburide in treating malignant cerebral edema. Blocking sulfonyl urea one (SUR1) receptors: T.V. Pallan & I. Ahmed; J. Vasc. Interv. Neurol. 7, 23 (2014)
  • In vitro biological evaluation of glyburide as potential inhibitor of collagenases: V.L. Bodiga, et al.; Int. J. Biol. Macromol. 70, 187 (2014)
  • NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury: Z. Liu, et al.; Inflammation 38, 433 (2015)

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