More Information Product Details Synonyms Product Type Properties Clone Isotype Immunogen/Antigen Application Crossreactivity Purity Detail Formulation Other Product Data Declaration Shipping and Handling Shipping Short Term Storage Long Term Storage Use/Stability Documents MSDS Product Specification Sheet Datasheet

ERT1; ERK2; MAPK1; ERK-2; MAPK 2; MAPK 1; p42-MAPK; EC=2.7.11.24; MAP Kinase 1; MAP Kinase 2; MAP Kinase Isoform p42; Mitogen-activated Protein Kinase 1; Mitogen-activated Protein Kinase 2

Monoclonal Antibody

1A8

Mouse IgG1 κ

Recombinant human His-Erk2 protein purified from E. coli.

ELISAWestern Blot (1:1,000)

HumanMouseRat

Ammonium sulfate precipitation.

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

Manufactured by AbFrontier

BLUE ICE

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

No

Download PDF

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase, and activates it as well. Once actived, Raf phosphorylates the other two kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in ERK 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4).Product References1) Smalley, K. (2003) Int. J. Cancer, 104, 527-532. (General)2) Johnson, G.L. and Lapadat, R. (2002) Science, 298, 1911-1912. (General)3) Kolch, W. (2000) Biochem. J. 351, 289-305. (General)

>>> 更多资讯详情请访问蚂蚁淘商城