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B7-H2; ICOS Ligand; B7-like Protein Gl50; B7RP-1

Monoclonal Antibody

ANC4E3

Mouse IgG1κ

Human Raji cells, recombinant human CD275-muIg.

Preservative Free

ELISA

Human

50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl

Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

Manufactured by Ancell Corporation.

BLUE ICE

+4°C

+4°C

Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at +4°C.

No

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The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology) and plays an analogous role in the T cell activation process. Signaling through CD278 is particularly important in progression of TH2 immune response. The receptor for human CD278 (ICOS) is CD275 (GL50), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2). Blockade of the CD278-CD275 interaction in mice improves allograft survival and reduces EAE.

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