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蚂蚁淘在线 / 品牌中心 / Adipogen品牌新闻

Adipogen/IHR-NAc/AG-CR1-3527-M001/1 mg

作者： 时间：2024-09-20 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW Purity Chemicals Appearance Solubility Identity InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
5-Acetamido-2-chloro-N-[4-(2,5-dichlorobenzamido)phenyl]benzamide
Chemical
C22H16Cl3N3O3
476.7
≥98% (NMR)
White to grey solid.
Soluble in DMSO.
Determined by 1H-NMR and HR-MS.
KEKPTYABAFCFOT-UHFFFAOYSA-N
AMBIENT
+4°C
-20°C
Protect from light.
Stable for at least 1 year after receipt when stored at -20°C.
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  • Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound.
  • Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo.
  • Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Product References
  • The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)

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