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蚂蚁淘在线 / 品牌中心 / Adipogen品牌新闻

Adipogen/Bafilomycin D (high purity)/BVT-0475-M001/1 mg

作者： 时间：2024-09-20 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW CAS Source/Host Chemicals Purity Chemicals Appearance Solubility Identity Declaration InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
Tubamycin; Antibiotic 3D5
Chemical
C35H56O8
604.8
98813-13-9
Semi-synthetic product formed from Bafilomycin B1.
≥98% (HPLC)
Off-white to yellow solid.
Soluble in DMSO, 100% ethanol, methanol, acetone or dichloromethane.
Determined by 1H-NMR.
Manufactured by BioViotica.
ZKOTUWJMGBWBEO-YXTSRGFTSA-N
AMBIENT
+4°C
-20°C
Protect from light when in solution.
Stable for at least 1 year after receipt when stored at -20°C.After reconstitution protect from light at -20°C.
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  • Macrolide antibiotic. Bafilomycin derivative, in which the characteristic hemiketal portion has been opened.
  • Potent and specific vacuolar-type H+-ATPase inhibitor (V-ATPase).
  • Antiproliferative agent against selected human glioma cell lines.
  • Cytoxic activity. Active against Gram-positive bacteria and plant pathogen fungi.
  • Shows weak insecticidal and anti-nematodic activity.
Product References
  • The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin: A. Kretschmer, et al.; Agric. Biol. Chem. 49, 2509 (1985)
  • Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Droese, et al.; Biochem. 32, 3902 (1993)
  • Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
  • Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Droese & K. Altendorf; J. Exp. Biol. 200, 1 (1997)
  • Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups: M. G. OShea, et al.; J. Antibiot. 50, 1073 (1997)
  • Bafilomycins and odoriferous sesquiterpenoids from Streptomyces albolongus isolated from Elephas maximus feces: N. Ding, et al.; J. Nat. Prod. 79, 799 (2016)
  • Bioactive bafilomycins and a new N -arylpyrazinone derivative from marine-derived Streptomyces sp. HZP-2216E: Z. Zhang, et al.; Planta Med. (Epub ahead of Print) (2017)

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