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Interleukin-22; IL-10-related T Cell-derived-inducible Factor

Protein

CHO cells

The extracellular domain of mouse IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of mouse IgG2a.

Mouse

≥98% (SDS-PAGE)

Reconstitute at 100μg/ml in sterile PBS.

Lyophilized from 0.2μm-filtered solution in PBS.

NCBI reference NP_058667.1: IL-22 (mouse)

Manufactured by Chimerigen.

BLUE ICE

+4°C

-20°C

Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.

No

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Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rβ(CRF24), belonging to the class II cytokine receptor family.

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