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Viagra; Revatio

Chemical

C22H30N6O4S . C6H8O7

474.6 . 192.1

171599-83-0

≥95%

Solid.

Soluble in DMSO or ethanol.

Manufactured by SynKinase.

Target: PDE5 | Kinase Group: N/A | Substrate: N/AClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

DEIYFTQMQPDXOT-UHFFFAOYSA-N

AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

No

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Sildenafil citrate is an orally active selective inhibitor of cGMP-specific PDE5 (phosphodiesterase type 5), an enzyme that regulates blood flow in the penis and which is the predominant PDE isoenzyme in human corpora cavernosa. Sildenafil citrate is used as an agent to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Studies in vitro have shown that sildenafil has between 10 and 10,000-fold greater selectivity for PDE5 than for other phosphodiesterase isoforms (PDEs 1, 2, 3, 4, 6, 7 to 11). In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 mM).Product References

Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes: S.A. Ballard, et al.; J. Urol. 159, 2164 (1998)

Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds: I.V. Turko, et al.; Mol. Pharmacol. 56, 124 (1999)

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond: H.A. Ghofrani, et al.; Nat. Rev. Drug Discov. 5, 689 (2006)

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